YM-254890

for Cellbiology

This product is for research use only. Do not administer it to humans.

Trimeric G proteins, G_q family specific inhibitor.

This is a cyclic depsipeptide isolated from a soil bacterium Chromobacterium sp. QS3666 strain and has a cyclic peptide structure composed of unique amino acids differing from normal amino acids.

It specifically inhibits signals mediated by G_q family of trimeric G proteins, G_q, G₁₁ and G₁₄, which are involved in elevated Ca²⁺ level among about 20 types of G proteins, by acting on GDT/GTP exchange reaction. It is a first membrane permeable compound particularly inhibiting G_q signal and a useful tool for a study analyzing G_q signals.

• Specifically inhibits signals mediated by G_αaq, G_α11, and G_α14

• Acts in both in vivo and in vitro systems

How to use: dissolve it in DMSO at 1-10 mmol/L to prepare stock solution. In use, accordingly dilute it with an experimental solution.

• Go through the stock solution as soon as possible.

Made by FUJIFILM Wako Pure Chemical Corporation and distributed by FUJIFILM Irvine Scientific

• For research use only. Not for use in diagnostic procedures.

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