Y-27632, MF

In stock

Catalog ID

259-00613, 257-00614

Size	Stock	SKU	Unit Price	Qty
5 mg	Inquire for Availability	259-00613	$605.00
25 mg	In Stock	257-00614	$2,420.00

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Details

This product is registered in the Drug Master File in Japan.

It is a selective and potent inhibitor of ROCK (Rho-associated coiled-coil forming kinase/Rho binding kinase).

Y-27632 has a variety of activities including vascular smooth muscle contraction through the ROCK signaling (Ki = 140 nmol/L p160ROCK). This product has been reported to suppress death of human ES cells and human iPS cells at the time of cell dispersion, and also improve viability of the cells after cryopreservation.
[ROCK : Rho-associated coiled-coil forming kinase]

This product is for research use only. Do not administer it to human.

Applications/Properties

For Cell Culture

Manufacturer:	FUJIFILM Wako Pure Chemical Corporation
Specification Assay:	98.0+% (HPLC)
CAS RN:	331752-47-7
Molecular Formula:	C14H21N3O・2HCl・H2O
Molecular Weight:	338.27
GHS:	Warning
Precautions for Use:	Packed on inactive gas
Appearance:	White - pale yellow, crystalline powder - powder
Boiling Point:	About 85°C
Specific Rotation:	+2.0 - +10.0°(D/20°C)(c=1.0,CH3OH)
Purity:	Bacterial endotoxins : <0.25 EU/mg
Alias:	(R)-(+)-trans-N-(4-Pyridyl)-4-(1-aminoethyl)cyclohexanecarboxamide Dihydrochloride Monohydrate

Preparation:

Solubility Data for Y-27632 dihydrochloride

C14H21N3O・2HCl・H2O = 338.27

	Solvent	Conc. mg/mL	Conc. mmol/L
Solubility	Water	10 mg/mL	29.56 mmol/L
	Ethanol	10 mg/mL	29.56 mmol/L

Preparing Stock Solutions

C14H21N3O・2HCl・H2O = 338.27

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mmol/L	2.956 mL	14.781 mL	29.562 mL
5 mmol/L	0.591 mL	2.956 mL	5.912 mL
10 mmol/L	0.296 mL	1.478 mL	2.956 mL
50 mmol/L	0.059 mL	0.296 mL	0.591 mL

Y-27632 Comparison Chart

	ICH-Q7	ISO9001	Sterility test	Viable count test	Animal- derived- free	Bacterial Endotoxin test	Mycoplasma test	Powder/ Liquid	References*
Y-27632 (GMP-compliant)**	✓	✓	-	✓	✓	✓	✓	Powder	-
Y-27632, MF***	-	✓	-	✓	✓	✓	✓	Powder	Link
CultureSure Y-27632	-	✓	-	-	✓	✓	✓	Powder	Link
CultureSure 10mmol/L Y-27632 Solution, Animal-derived-free	-	✓	✓	-	✓	✓	✓	Liquid Sterilized with filter	Link

* Click to move to the PubMed Central search results.
** This product is complied with ICH-Q7 (GMP for APIs) as a raw material for commercial production of regenerative medicine products.
*** The manufacturing process and analytical procedure are validated.

Made by FUJIFILM Wako Pure Chemical Corporation and distributed by FUJIFILM Irvine Scientific

For research use or further manufacturing use only. Not for use in diagnostic procedures.
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