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Achieve Reliable MSC Expansion While Reducing Raw Material Risk
Xeno- and serum-free human mesenchymal stromal/stem cell (MSC) expansion medium
PRIME-XV MSC Basal XSFM provides control and consistency over MSC outcomes by enhancing cell growth and viability at every stage of research and development.
Optimized for 5% human platelet lysate (hPL) supplementation using PLTGold and PLTMax or other supplements designed to support MSC culture
Maintains MSC quality after extended culture
Supports expansion of MSCs derived from human adipose, human bone marrow, and human umbilical cord
Xeno-free and serum-free formulation ensures consistent and reproducible outcomes
GMP-ready for preclinical research and scale-up
PRIME-XV MSC Basal XSFM + hPL Enhances Expansion
Population Doubling Over 14-Day Expansion
Figure 1. PRIME-XV MSC Basal XSFM supplemented with 5% hPL significantly outperforms α-MEM supplemented with 5% hPL. After 14 days of MSC expansion, PRIME-XV MSC Basal XSFM supplemented with 5% hPL (PLTGold-GI, Mill Creek) outperforms αMEM (with nucleosides) supplemented with 5% hPL by ~2 total population doublings (i.e., ~4-fold greater expansion) and αMEM without nucleosides by ~4 total population doublings (i.e. ~16-fold greater expansion).
Supports Robust Expansion of MSCs from Various Tissue Sources
MSC Expansion Across Four Passages (14 Days of Culture)
Figure 2. PRIME-XV MSC Basal XSFM supplemented with 5% hPL successfully supports expansion of various sources of hMSCs. Over 4 passages of culture, PRIME-XV MSC Basal XSFM supplemented with 5% hPL (PLTGold-GI, Mill Creek) supports reliable expansion of hMSCs across 3 different tissue origins. Each data point represents the average of a single donor, with a total of 3 donors tested per tissue origin.
Maintains MSC Phenotype Across 3 Tissue Sources
Sample
CD73
CD90
CD105
CD34
CD45
CD14
CD19
HLA-DR
BM-MSC
100.0%
100.0%
99.1%
0.11%
0.114%
0.021%
0.067%
0.016%
AD-MSC
99.5%
99.8%
99.7%
0.036%
0.036%
0.042%
0.125%
0.003%
UC-MSC
100.0%
100.0%
97.5%
0.056%
0.056%
0.036%
0.043%
0.027%
The surface marker data show the average of 3 different donors for each source of hMSC measured after 4 passages. Positive markers (CD73, CD90, CD105) are maintained, negative markers (CD34, CD45, CD14, CD19, HLA-DR) remained low.
Global Supply Continuity for Cell Therapy
PRIME-XV MSC Basal XSFM is manufactured following GMP using qualified raw materials to ensure continuity of supply and lot-to-lot reliability from our facilities all over the world.
Stringent raw materials control and sourcing program
Meets the highest global and regional quality standards
Fulfills regulatory demands for each lot
COA, COO, TSE/BSE statements
ISO 13485, EN 13485:2016 certified
Drug Master Files (DMF) supported*
*Available upon request
For research or further manufacturing use only.
Custom sizes and packaging available upon request.
Contact us for international pricing and custom formulations.
Specifications
Size
500 mL
Storage
This product is shipped at 2-8°C with cold packs. Upon receipt, store immediately at 2-8°C and protect from light.
Shelf Life
Handle using aseptic techniques to avoid contamination. Unopened liquid medium is stable for 12 months from date of manufacture, as indicated on the label.
