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This device is restricted to be sold to and used by licensed healthcare practitioners for assisted reproduction procedures in a clinical laboratory setting.
Continuous Single Culture-NX Complete (CSCM-NXC) is a clinically-proven, low lactate, single-step culture medium that helps improve blastocyst development. It is intended for use in assisted reproductive procedures which include human gamete and embryo manipulation. These procedures include the use of CSCM-NXC as a culture medium from fertilization through blastocyst stage, as well as embryo transfer. This medium is optimized to be used in an uninterrupted culture system, without dish change or medium renewal.
Pre-supplemented with human serum albumin (HSA) for a final total protein concentration of 5 mg/mL.
Unlock the Full Potential of CSCM-NXC with the Day 0 Workflow
Introducing oocytes into CSCM-NXC on Day 0 directly after identification, instead of waiting until after fertilization, maintains a consistent environment while eliminating dish changes and simplifying your workflow.
Day 0 with CSCM-NXC
Traditional Method
*Dish must be changed after conventional insemination. ICSI performed per established lab procedures with buffered media.
Better Results Start at Day 0
Studies show that when labs follow the Day 0 workflow with CSCM-NXC, they see significant improvements in embryo culture outcomes.
Overall higher Day 5 and 6 blastocyst utilization rate (BUR), even when accounting for patient age1,2
Increase BUR in patient population >38 years old3
Higher euploidy rate than CSCM4
Improvement in clinical pregnancy and reduction in miscarriage rates5
Increase in higher expansion grade blastocysts6
Improved trophectoderm and inner cell mass grades6
Reduced embryo discards6
CSCM-NX/C vs. Competitors
*Differences were significant (p<0.05)
† More usable blasts in traditional media on Day 6 due to higher BUR on Day 5 in low lactate media.
Results complied from clinical use data collected from 2020—2023.
Check out our Day 0 webinar to learn how you can implement this protocol in your lab.
Benini F, Watson L, Dusini S, A Degl”Innocenti, Adversi F, Cammunci S, Di Biase L, F Bertini, Benvenuti M. A low-lactate undisturbed culture medium protocol provides an increase in usable blastocysts on day 5 vs. day 6. Human Reproduction. 2022;37(1). deac107.254
Manzo R, Listorti I, Colasante A, Scarselli F, Greco P, Arrivi C, Watson L, Greco A, Varricchio M.T., Pirastu G, Musella M, Barberi M, Uva D, Pristera’ A, Greco E. A continuous culture medium with a lower concentration of lactate has a pronounced effect on the percentage of usable blastocysts on day 5. Human Reproduction. 2022;37(1). deac107.256
Hammond E, Morbeck D. Reducing the stress of culture? Low lactate embryo culture medium increases usable blastocyst rate for women of advanced maternal age. Fertility and Sterility. 2020;114(3); e7-e7
Whitney JB, Watson L, Maizar A, VerMilyea M. Positive effects of low-lactate culture medium on embryo development and blastocyst ploidy status: a 3.5-year multi-clinic retrospective review. Human Reproduction. 2022; 37 (1). deac107.217
Kobanawa M. Fertilization, embryo culture, and clinical results using low lactate embryo culture medium for pre-culture, insemination, and beyond. Reprod Med Biol. 2022;21(1):e12458. doi:10.1002/rmb2.12458
Moreno Moya JM, Mansell S, Alland I, Øverlie I, Sørdal T, Finset M. CSCM-NXC media containing a low lactate concentration seems to benefit expansion grade compared to traditional continuous media. Human Reproduction. 2022; 37(1), deac104.080
