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Achieve High Productivity in CHO-MK Cells for Advanced Biologics
Specifically designed for CHO-MK1,2 cell cultures using fed-batch processes for mAbs production, AdaptPD CHO-MK Medium A and AdaptPD CHO-MK Feed 1 are a chemically defined, growth and feed media pairing to maximize high cell density growth and titers.
Achieve titers up to 10-12 g/L, compared to conventional CHO cell cultures
Proliferate higher cell growth in 4-7 days, compared to standard 14-day culturing
Utilize scalable and adaptable workflows from small-scale flasks to large-scale bioreactors
Surpass conventional methods for the novel CHO-MK cell line by exceeding performance in cell growth, titer, and viability versus conventional CHO host cell lines
Expedite mAb Therapies With Higher Growth and Titers
High Productivity in Shake Flask and Bioreactor Scales
Figure 1. Growth and titer of CHO-MK cell line producing mAb (Trastuzumab) in shake flask and bioreactor. (A) CHO-MK cells were cultured in 125 mL baffled flask using AdaptPD CHO-MK Medium A and AdaptPD CHO-MK Feed 1. Titer was measured on Day 7, achieving 11.3 g/L with 89.4% viability and maximum viable cell density (VCD) at 5.7 x 107 cells/mL. Cell-specific productivity was 60.5 pg/cell/day (Day 0–7). (B) CHO-MK cells were cultured in a 2 L bioreactor (Biott, Japan) using AdaptPD CHO-MK Medium A and AdaptPD CHO-MK Feed 1. Titer was measured on Day 7, achieving 11.7 g/L with 81.2% viability and maximum VCD at 4.6 x 107 cells/mL. Cell-specific productivity was 64.3 pg/cell/day (Day 0–7).
Figure 1. Growth and titer of CHO-MK cell line producing mAb (Trastuzumab) in shake flask and bioreactor. (A) CHO-MK cells were cultured in 125 mL baffled flask using AdaptPD CHO-MK Medium A and AdaptPD CHO-MK Feed 1. Titer was measured on Day 7, achieving 11.3 g/L with 89.4% viability and maximum viable cell density (VCD) at 5.7 x 107 cells/mL. Cell-specific productivity was 60.5 pg/cell/day (Day 0–7). (B) CHO-MK cells were cultured in a 2 L bioreactor (Biott, Japan) using AdaptPD CHO-MK Medium A and AdaptPD CHO-MK Feed 1. Titer was measured on Day 7, achieving 11.7 g/L with 81.2% viability and maximum VCD at 4.6 x 107 cells/mL. Cell-specific productivity was 64.3 pg/cell/day (Day 0–7).
Currently Working With CHO-MK Cells or New to This Platform?
Contact us for more information on AdaptPD CHO-MK Platform Media and for access details to get started on the CHO-MK cell line platform.
AdaptPD CHO-MK Medium A and AdaptPD CHO-MK Feed 1 are manufactured following GMP using qualified raw materials to ensure continuity of supply and lot-to-lot reliability from our facilities all over the world.
Stringent raw materials control and sourcing program
Meets the highest global and regional quality standards
Fulfills regulatory demands for each lot
COA, COO, TSE/BSE statements
ISO 13485, EN 13485:2016 certified
Drug Master Files (DMF) supported*
*Available upon request
For research or further manufacturing use only.
Custom sizes and packaging available upon request.
