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The ability to produce high product titers and excellent protein quality is critical for the generation of effective therapeutic biomolecules. Glycosylation modifications, including galactosylation, help to achieve this critical quality aspect by enhancing protein characteristics and antibody efficacy. BalanCD Gal Supplement delivers increased galactosylation, through the addition of N-linked glycan moieties, while supporting an efficient, streamlined workflow.
Compatible with any basal growth medium for a wide range of cell lines
Simplified, scalable protocol
Enhanced formula requires a lower concentration to achieve desired outcome—contributing to improved efficiency and streamlined workflow
Simple, single feeding schedule
Chemically-defined, animal component-free, and cGMP manufactured to support commercial applications
Designed to incorporate seamlessly into the BalanCD CHO Media Platform for efficient growth and production
Standard Packaging Size: 100 mL bottle
Custom Packaging Size: 1 L Made-to-Order only.
Please contact us to place an order for 1 L bottles or get more information.
Increase Galactosylation with a Simplified Feeding Protocol
Figure 1. Percent galactosylation from CHO fed-batch cultures expressing a model antibody. BalanCD Gal Supplement was added on day 7 of cultures at 0.4-1.8% (v/v). Supplement from Supplier A was added according to the manufacturer’s protocol, on days 2-10 every other day for a total of 0.5-2.0% (v/v). The fed-batch control (Control) without any supplementation resulted in about 15% antibody galactosylation. BalanCD Gal Supplement resulted in up to 50% galactosylation with as little as 1.1% supplementation. The supplement from Supplier A resulted in about 45% galactosylation even at the highest recommended concentration of 2.0%. Data shown represents the average of two replicate cultures.
