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An Enhanced Feed for Evolving mAb Process Platforms
Designed to improve manufacturability and process efficiencies, BalanCD CHO Feed 4 Evo is an evolved formulation with increased stability and simplified hydration for scale-up. Leverage a high-performing feed for consistency upstream and confidence in your development downstream.
Amplify titers across small- to large-scale process development and manufacturing
Drive high productivity with increased media stability and a simplified hydration process
Support a range of CHO subtypes for optimization to your platform
Improved Stability for Consistent Performance
Figure 1. Cell growth is comparable to BalanCD CHO Feed 4 and supported with liquid feed stored for 6 weeks. Cell growth (viability and viable cell density [VCD]) was measured in CHO DG44 fed-batch cultures using BalanCD CHO DG44 growth medium supplemented with BalanCD CHO Feed 4 (1X, freshly prepared), BalanCD CHO Feed 4 Evo (1X, freshly prepared), or BalanCD CHO Feed 4 Evo (1X, prepared and stored at 2–8°C for 6 weeks). Hydrated powder feed media (containing 20 g/L glucose) was supplemented with 28 g/L glucose at the time of hydration. Feeding strategy was the same for all 3 feeds. Refer to recommended protocol for additional feeding strategy details.
Figure 1. Cell growth is comparable to BalanCD CHO Feed 4 and supported with liquid feed stored for 6 weeks. Cell growth (viability and viable cell density [VCD]) was measured in CHO DG44 fed-batch cultures using BalanCD CHO DG44 growth medium supplemented with BalanCD CHO Feed 4 (1X, freshly prepared), BalanCD CHO Feed 4 Evo (1X, freshly prepared), or BalanCD CHO Feed 4 Evo (1X, prepared and stored at 2–8°C for 6 weeks). Hydrated powder feed media (containing 20 g/L glucose) was supplemented with 28 g/L glucose at the time of hydration. Feeding strategy was the same for all 3 feeds. Refer to recommended protocol for additional feeding strategy details.
Growth and Productivity in Multiple CHO Subtypes
Figure 2. Antibody titer production is comparable to BalanCD CHO Feed 4 and supported with liquid feed stored for 6 weeks. Titer (A) and peak productivity (Qp) measured on Day 13 (B) in CHO DG44 fed-batch cultures using BalanCD CHO DG44 growth medium supplemented with BalanCD CHO Feed 4 (1X, freshly prepared), BalanCD CHO Feed 4 Evo (1X, freshly prepared), or BalanCD CHO Feed 4 Evo (1X, prepared and stored at 2–8°C for 6 weeks).
Figure 2. Antibody titer production is comparable to BalanCD CHO Feed 4 and supported with liquid feed stored for 6 weeks. Titer (A) and peak productivity (Qp) measured on Day 13 (B) in CHO DG44 fed-batch cultures using BalanCD CHO DG44 growth medium supplemented with BalanCD CHO Feed 4 (1X, freshly prepared), BalanCD CHO Feed 4 Evo (1X, freshly prepared), or BalanCD CHO Feed 4 Evo (1X, prepared and stored at 2–8°C for 6 weeks).
Global Supply Continuity for Bioproduction
BalanCD CHO Feed 4 Evo is manufactured following GMP using qualified raw materials to ensure continuity of supply and lot-to-lot reliability from our facilities all over the world.
Stringent raw materials control and sourcing program
Meets the highest global and regional quality standards
Fulfills regulatory demands for each lot
COA, COO, TSE/BSE statements
ISO 13485, EN 13485:2016 certified
Drug Master Files (DMF) supported*
*Available upon request.
For research or further manufacturing use only.
Custom sizes and packaging available upon request.
Contact us for international pricing and custom formulations.
